ABSTRACT
Statins are the most widely used drugs for reducing lipid and cholesterol levels in the blood. However, statins have shown some adverse effects and less acceptance among patients; hence, new drugs have been promoted in the market. Furthermore, gemcabenes were discovered in 1995 and are now in phase II and III clinical trials. Gemcabene acts by inhibiting incorporation of 14C-acetate into hepatocytes and stops the mechanism of fatty acids and cholesterol synthesis. In this review the six randomized controlled trials (RCTs) were scrutinized from the two databases by using keywords "Gemcabene" AND "Randomized Controlled Trial." The trials were mainly on animal models, and two studies were found to be associated with human subjects. The study concluded that gemcabene was effective as an anti-inflammatory agent and reduced lipid levels and the progression of fibrosis. Hence, further controlled trials are needed to determine its efficacy and safety in human subjects, along with the identification of adverse effects.
ABSTRACT
BACKGROUND Coronavirus disease 2019 (Covid-19) originating in Wuhan, China in December 2019 spread worldwide rapidly. It was declared as a global public health emergency, and subsequently as a pandemic by the WHO, owing to its worldwide spread. Currently, Covid-19 is of the gravest concern because of its high transmissibility, high mortality, rapid global spread, lack of knowledge about the disease and lack of management resources. Lockdown and self-quarantine measures have been implemented globally by various nations to mitigate the spread of Covid-19. In several nations, fitness centres and other public places, where people are normally active, had been temporarily closed to prevent further spread of infection. Being quarantined at home for extended periods makes it challenging to stay physically active. Recent studies demonstrated that regular physical activities and exercises lower the incidence of several communicable diseases, including the novel Covid-19 by enhancing the immune system. Regular exercises improve the components of physical fitness, which include muscular strength, cardiorespiratory fitness, coordination, balance and agility, which in turn, enhance the physiological functions of the body. Regular exercises and relaxation techniques are some significant approaches aimed at improving one's overall health during the quarantine. Since organizations and governments worldwide had advised physical activity in quarantine, and also because regular physical activity is beneficial for both the physical and mental health, its role in the quarantine is significant. This review highlights the significance of physical activity and exercise in enhancing the well-being of individuals during the quarantine phase of Covid-19 pandemic.
ABSTRACT
BACKGROUND Since December 2019, a novel coronavirus, SARS-CoV-2, has been identified in a group of community acquired pneumonia patients in Wuhan, Hubei Province, China.(1) Within one month of its discovery, this novel coronavirus was rapidly spreading in all regions of China and 25 countries in Asia-Pacific region, Europe, and South America, North America. With the COVID 19 pandemic rapidly spreading in India and the world, it is imperative that the rehabilitation team understands virus's epidemiology quickly at the beginning stages of this certainly long global epidemic. Coronavirus is a novel virus, and it has no known immunity for most of the world population. This is more contagious and lethal than influenza viruses, and effective medication and a vaccine are months away. Our strategy against this is primarily social distancing and interventions to manage infections.